What is Rhupus?
- Tanya Freirich
- 1 hour ago
- 3 min read
Rhupus, also sometimes called rhupus syndrome, is an overlap between both lupus and rheumatoid arthritis (RA). This means that patients with rhupus experience characteristics of both autoimmune diseases simultaneously. Since it's considered an overlap syndrome, it shares many of the same symptoms and is often tricky to diagnose.
Differences Between Rheumatoid Arthritis and Lupus
Before we cover rhupus specifically, let's talk about lupus versus rheumatoid arthritis (RA). Both are autoimmune diseases that cause inflammation and joint pain in the body. However, RA affects the smaller joints in the hands and feet, which leads to chronic swelling. By contrast, lupus can affect organs and tissues in the body with more variable and less predictable flare-ups. Rhupus is when patients have symptoms of both diseases present at the same time.

Both RA and lupus are considered to be medical mysteries, as the exact causes are unknown. Many experts in the field believe that both RA and lupus could potentially be caused by hormones, genes, and the environment, though the exact cause is still not proven.
In both diseases, a similar shift in biology is observed where the body turns against itself. Instead of protecting healthy tissues and bodily systems as it normally would, the immune system attacks itself, causing an influx of inflammatory responses and issues throughout the body.
Symptoms and Characteristics of Rhupus
Generally speaking, there are some common things to look for when it comes to rhupus. Here are some of the symptoms many patients experience:

joint pain (small joints as well as larger ones)
chronic inflammation
extreme fatigue
skin rashes
Since many of the characteristics and symptoms between lupus and RA are so similar, it can be hard to distinguish which disease a patient is experiencing.
Rhupus is also a rare condition, with estimates published by the NIH showing a prevalence is around 0.09%.
Treatment for Rhupus
Rhupus is treated by providing medical care for RA and lupus individually. Most patients require a combination of different medications to effectively manage symptoms. Remember, though, for most autoimmune diseases, medication is only one factor in the equation.
Lifestyle changes play an important role in the overall quality of life and should not be overlooked. By making modifications in a few areas, patients with rhupus can reduce flare-ups, have increased energy, and generally feel better day to day. Here are some of the important things to consider:
Movement - Being intentional to get daily movement can dramatically improve symptoms, mood, and sleep quality. Focus on something you enjoy to ensure sustainability. Don't underestimate the power of even 5 minute movement breaks - extra walking, stretching and even light weights or bodyweight exercise breaks keep your joints moving and can help you feel less stiff.

Stress Management - Finding a healthy way to manage stress is crucial in bringing inflammation down in the body. Consider practices such as meditation, journaling, or reading to manage stress. Also, think about the places in your life you can reduce the stress: pause extra commitments, establish firmer boundaries or reduce time watching stressful news coverage?
Sleep - Adequate sleep is probably the most underrated form of therapy for any disease out there. When our bodies are deprived of quality sleep, we cannot undergo the nightly repair and restoration process. This, in turn, increases inflammation and ultimately the symptoms of rhupus.
Proper Nutrition - A key factor in managing rhupus, as well as RA and lupus individually, is proper nutrition. An anti-inflammatory diet rich in antioxidants from fruits and vegetables, as well as inflammation-fighting omega-3 sources, is generally considered best. Patients should aim to get a balance of healthy proteins, a wide variety of fruits and vegetables, and limit processed foods for best results.
Get Support with Rhupus
I know that this diagnosis is a challenging one. As the Lupus Dietitian, I came to this field after my own lupus diagnosis nearly 11 years ago. While these symptoms are frustrating and difficult to manage, there are things you can do.

Speaking from my own experience, as well as the stories of my clients, nutrition therapy can have a lasting impact on your health and overall quality of life. In fact, since making lifestyle and dietary changes in my own life, I haven't had a flare-up in nearly 10 years! The bottom line? You can THRIVE with lupus, RA, or rhupus! I promise.
To learn more about how to get started on your journey towards better health, book a 15-minute discovery call with me. I have a wide range of options and programs, from 1:1 nutrition counseling and customized testing to group programs. I know we can find the right fit for you to help manage your symptoms and feel your best!
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